Extra residue mutations for knobs-into-holes (KIH) formats13are typically utilized to create heavy-chain heterodimers by introducing mutations in the CH3 domains, while introduction of positively and negatively billed residues in the CH1 and CLdomains of 1 arm14assist in the right pairing of light and weighty chains to help make the preferred asymmetric antibody format even more favorable
Extra residue mutations for knobs-into-holes (KIH) formats13are typically utilized to create heavy-chain heterodimers by introducing mutations in the CH3 domains, while introduction of positively and negatively billed residues in the CH1 and CLdomains of 1 arm14assist in the right pairing…