The classical K48-linked polyubiquitination targets the substrate for proteasomal degradation, whereas the K63-linked chains are involved in non-proteolytic regulation such as protein complex formation and kinase activation (Chen and Sun, 2009)
The classical K48-linked polyubiquitination targets the substrate for proteasomal degradation, whereas the K63-linked chains are involved in non-proteolytic regulation such as protein complex formation and kinase activation (Chen and Sun, 2009). its phosphorylation and association of TCR- and Zap-70. Therefore,…